epipen trainer suppliers

DESCRIPTION
The EpiPen® and Epipen® Jr auto-injectors contain 2 mL epinephrine injectionfor emergency intramuscular use epipen trainer suppliers. Each EpiPen® auto-injector delivers a singledose of 0.3 mg epinephrine from epinephrine injection, USP, 1:1000 (0.3 mL)in a sterile solution epipen trainer suppliers.

Each EpiPen® Jr auto-injector delivers a single dose of 0.15 mg epinephrinefrom epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile solution epipen trainer suppliers.

For stability purposes, approximately 1.7 mL remains in the auto-injector afteractivation and cannot be used epipen trainer suppliers.

Each 0.3 mL in EpiPen® contains 0.3 mg epinephrine, 1.8 mg sodium chloride,0.5 mg sodium metabisulfite, hydrochloric acid to adjust pH, and Water for Injection epipen trainer suppliers. The pH range is 2.2-5.0 epipen trainer suppliers. Each 0.3 mL in EpiPen® Jr contains 0.15 mg epinephrine,1.8 mg sodium chloride, 0.5 mg sodium metabisulfite, hydrochloric acid to adjustpH, and Water for Injection epipen trainer suppliers. The pH range is 2.2-5.0 epipen trainer suppliers.

Epinephrine is a sympathomimetic catecholamine epipen trainer suppliers. Chemically, epinephrine isB-(3, 4-dihydroxyphenyl)-a-methyl-aminoethanol, with the following structure:

It deteriorates rapidly on exposure to air or light, turning pink from oxidationto adrenochrome and brown from the formation of melanin epipen trainer suppliers. Epinephrine solutionswhich show evidence of discoloration should be replaced.
CLINICAL PHARMACOLOGY
Epinephrine is a sympathomimetic drug, acting on both alpha and beta receptors epipen trainer suppliers. It is the drug of choice for the emergency treatment of severe allergic reactions(Type I) to insect stings or bites, foods, drugs, and other allergens epipen trainer suppliers. It canalso be used in the treatment of idiopathic or exercise-induced anaphylaxis epipen trainer suppliers. Epinephrine when given subcutaneously or intramuscularly has a rapid onset andshort duration of action epipen trainer suppliers. The strong vasoconstrictor action of epinephrine throughits effect on alpha adrenergic receptors acts quickly to counter vasodilationand increased vascular permeability which can lead to loss of intravascularfluid volume and hypotension during anaphylactic reactions epipen trainer suppliers. Epinephrine throughits action on beta receptors on bronchial smooth muscle causes bronchial smoothmuscle relaxation which alleviates wheezing and dyspnea epipen trainer suppliers. Epinephrine also alleviatespruritis, urticaria, and angioedema and may be effective in relieving gastrointestinaland genitourinary symptoms associated with anaphylaxis epipen trainer suppliers.

INDICATIONS AND USAGE
Epinephrine is indicated in the emergency treatment of allergic reactions (anaphylaxis)to insect stings or bites, foods, drugs and other allergens as well as idiopathicor exercise-induced anaphylaxis epipen trainer suppliers. The EpiPen® and EpiPen® Jr auto-injectorsare intended for immediate self-administration by a person with a history ofan anaphylactic reaction epipen trainer suppliers. Such reactions may occur within minutes after exposureand consist of flushing, apprehension, syncope, tachycardia, thready or unobtainablepulse associated with a fall in blood pressure, convulsions, vomiting, diarrheaand abdominal cramps, involuntary voiding, wheezing, dyspnea due to laryngealspasm, pruritis, rashes, uticaria or angioedema epipen trainer suppliers. The EpiPen® and EpiPen®Jr are designed as emergency supportive therapy only and are not a replacementor substitute for immediate medical or hospital care epipen trainer suppliers.

CONTRAINDICATIONS
There are no absolute contraindications to the use of epinephrine in a life-threateningsituation epipen trainer suppliers.

WARNINGS
Epinephrine is light sensitive and should be stored in the tube provided epipen trainer suppliers. Storeat room temperature (15°-30°C/59°-86°F) epipen trainer suppliers. Do not refrigerate epipen trainer suppliers. Before using, check to make sure the solution in the auto-injector is not discolored epipen trainer suppliers. Replace the auto-injector if the solution is discolored or contains a precipitate epipen trainer suppliers. Avoid possible inadvertent intravascular administration epipen trainer suppliers. EpiPen® and EpiPen®Jr should only be injected into the anterolateral aspect of the thigh epipen trainer suppliers. DO NOTINJECT INTO BUTTOCK epipen trainer suppliers.

Large doses or accidental intravenous injection of epinephrine may result incerebral hemorrhage due to sharp rise in blood pressure epipen trainer suppliers. DO NOT INJECT INTRAVENOUSLY epipen trainer suppliers. Rapidly acting vasodilators can counteract the marked pressor effects of epinehrine epipen trainer suppliers.

Epinephrine is the preferred treatment for serious allergic or other emergencysituations even though this product contains sodium metabisulfite, a sulfitethat may in other products cause allergic-type reactions including anaphylacticsymptoms or life-threatening or less severe asthmatic episodes in certain susceptiblepersons epipen trainer suppliers. The alternatives to using epinephrine in a life-threatening situationmay not be satisfactory epipen trainer suppliers. The presence of a sulfite in this product should notdeter administration of the drug for treatment of serious allergic or otheremergency situations epipen trainer suppliers.

Accidental injection into the hands or feet may result in loss of blood flowto the affected area and should be avoided epipen trainer suppliers. If there is an accidental injectioninto these areas, advise the patient to go immediately to the nearest emergencyroom for treatment epipen trainer suppliers. EpiPen® and EpiPen® Jr epipen trainer suppliers. should only be injectedinto the anterolateral aspect of the thigh epipen trainer suppliers.

PRECAUTIONS
Epinephrine is essential for the treatment of anaphylaxis epipen trainer suppliers. Patients with a historyof severe allergic reactions (anaphylaxis) to insect stings or bites, foods,drugs, and other allergens as well as idiopathic and exercise-induced anaphylaxisshould be carefully instructed about the circumstances under which this life-savingmedication should be used epipen trainer suppliers. It must be clearly determined that the patient isat risk of future anaphylaxis, since the following risks may be associated withepinephrine administration (see Dosage and Administration ) epipen trainer suppliers.

Epinephrine is ordinarily administered with extreme caution in patients whohave heart disease epipen trainer suppliers. Use of epinephrine with drugs that may sensitize the heartto arrhythmias, e.g., digitalis, mercurial diuretics, or quinidine, ordinarilyis not recommended epipen trainer suppliers. Anginal pain may be induced by epinephrine in patients withcoronary insufficiency epipen trainer suppliers.

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